They need a majority in the Senate and the House to do anything significant. So crossing fingers.
Obamacare needs its minor fixes. And the loan system for higher education is just driving up prices and leaving a typical student with a mortgage over their career, which isn't a good thing if you also want people to take risks with innovative ideas to deliver a stronger economy. Massive loans are the new form of serfdom. But it's serfdom to the banks and employers, rather than to the manorial lords of yesteryear.
At least court vacancies can be filled with a Senate majority.