Indeed it does, sir! It's designed for Fermi cards which I believe start with the 400 series. I've seen numerous success postings on 460's and I've completed a number now myself on my 550ti. It will work on Keplers too.
All you need to do in 6.41 is add the -betateam flag, same as you would the -advmethods or -config flag. There are theories that you need ver 7 or Core 2.25 or 2.22 but you don't, the thing you need is the -betateam flag. 2.22 runs a heckuva lot faster on ALL WU's btw, except the 762x series which actually requires 2.25. That however is a different issue.
You'll know it's configured properly if the current WU ends and you then get the magic 8057 or the non-magic but still beta 8018. There's a small chance you'll get a 762x if a server's down. You get any of those and that means your configuration's ready, it's just a matter of waiting. My first took a week, I had figured I had simply done something wrong and couldn't see it.
That's really all there is, but come back with any ?'s.