http://www.washingtonpost.com/health/2021/05/18/immunocompromised-coronavirus-vaccines-response/
Certain drugs taken negatively affect immune response, it seems.
That’s why the CDC does not recommend taking Tylenol or anything like that preventively after a shot, but only if and when symptoms arise, like fever, headache, etc.
That’s also part of the reason for perhaps breakthrough infections. A friend told me that a couple in Greece, friends of his, had an antibody test done, after the second dose of Pfizer, and both showed no antibodies at all. They are in their 50s, I believe. Don’t know much else about any drugs or health problems in their case, but it somewhat explains to a degree the problem.